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Active zinc obtained from ultrasonic-electrical method could even improve the reaction efficiency by more than three times.
Finally, if the continuous gain in spectrometer sensitivity will hold, our method could even be applied using N natural abundance and would allow the analysis of proteins with no heterologous expression.
Since the sample requirement is small and the method allows for analysis of membrane potential even if some mitochondria are disrupted during sample preparation, this method could even be applied to studies in which minimal amounts of samples are available (e.g., human tissue).
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Addition of other potential markers reported (Wentzensen et al, 2009; Lai et al, 2010; Overmeer et al, 2011; Lendvai et al, 2012; Bierkens et al, 2013; Verhoef et al, 2014) or identification of even better differentially methylated genes by genome-wide methods could even further improve the diagnostic accuracy of DNA methylation in the future.
This method could detect even targets with extremely low expression levels (less than a single mRNA copy per cell in whole brain tissue).
Our proposed method could work even for cases where the cells of interest are present in relatively low concentrations (e.g. less than 3%) provided that the range of concentrations is sufficiently wide.
A recent study showed high sensitivity (93%) and specificity (96%) when nodes were analysed according to their signal patterns, and this method could assess even small nodes <5 mm in diameter.
Certainly it offers the ability to create much more customizable parts than traditional methods – and could even help return local manufacturing for hardware startups, as a more lightweight and elastic system.
In addition, our method could be used at even higher imaging densities with many overlapped spots taking advantage of that the peak positions of each spot are pre-determined by the applied voltage.
Furthermore, using AXS and elastic constant measured by nanoindentation (ENIP) to calculate X-ray stress, the stress deviation from that by laser curvature method could be substantially reduced even down to 3% with sufficient sampling points.
In another method described, the system could even automatically distribute photos to people identified within them if the user has opted in to auto uploads.
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