However, these imaging methods cannot reliably confirm or exclude the presence of lymph node metastasis [ 1].
The problem arises from the fact that current staging methods cannot reliably exclude small metastases.
Consequently, typical automated methods cannot reliably assign such sequences to their homologous groups.
However, such a focus bears another set of problems: (1) Today's computational methods cannot reliably distinguish between gain and loss of function.
Moreover, since standard neuroimaging methods cannot reliably distinguish radiation necrosis from tumor recurrence, 1HMRS may prove to be a highly beneficial modality in the post-irradiation care of patients with brain gliomas.
However, composition-based methods tend to give contrasting results when the methods are changed (see ref.14 for a benchmark study on 16 composition-based methods) and cannot reliably detect ancient HGT events (see refs12,13 for challenges).
Some automakers have criticized this method, saying that measurements cannot reliably predict how well restraints will protect people in actual rear-end collisions.
Therefore, in the current form, this method cannot be expected to reliably detect recent changes in incidence, which would be very important in monitoring a national epidemic.
A major limitation of this method, as with all 2D SDS-PAGE based methods, is that it cannot reliably visualize or produce analytical quantities of low abundance proteins that are present in less than 1000 copies per cell.
Second, in the absence of a certain 'ground truth' that another empirical method can securely determine, one cannot reliably estimate the lesion component error without positing a hypothetical ground truth for the lesion-deficit association.
