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Exact(5)

As a result, the proposed assay method can sensitively determine the activity of corin with a detection limit of 0.92 pM, and can further be directly used in maternal plasma samples.

This is supportive evidence that our method can sensitively detect functional rare mutations; in other words, measuring pathway level impact of summarized rare mutational events is useful to prioritize the functional ones.

To assess whether our method can sensitively detect pathway aberrances that are associated with a patient's clinical outcome, a known survival pathway that showed strong association with patient survival from Beer's data was tested.

We have shown that the RHH method can sensitively detect ethnic outliers among samples mainly derived from a single ethnic group and have also shown the method's ability to visualize chromosomal mosaicism in many ethnically admixed individuals.

To evaluate whether our method can sensitively capture the impact of mutation event on the pathway level gene expression, we analyzed breast cancer data set from TCGA having paired somatic mutation and expression data (n = 513).

Similar(55)

After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect.

While EMSA, ChIP, luciferase assays, and 3C are widely applied and are mainstays in molecular genetic analysis, the development of high-throughput screening methods that can sensitively and accurately screen functional candidate variants would represent a significant technological breakthrough in this area.

The preferred and practical method is one that can sensitively, specifically and quickly detect EGFR mutations from specimens used for the diagnosis of lung cancers without removing contaminating normal cells.

As sequence alignment-based methods, on the contrary, BLAST and Pfam can sensitively detect some unique sequence patterns shared by a few T3SE proteins.

We anticipate that the NCD method used here also has value in those two industries because it can sensitively discriminate the closely related individuals they make use of when developing their breeding programs.

Such findings suggest that if conducted sensitively, and in a time appropriate manner, the deferred method can assist, rather than impede, parental decision making.

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