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Compared with the existing read-depth and read-pair approaches for SV identification, our method can pinpoint the exact breakpoints of SV events, reveal the actual sequence content of insertions, and cover the whole size spectrum for deletions.
Compared with the existing read-depth and read-pair analyses, our sequence-based method can pinpoint the exact breakpoints of indel/SV events, reveal the actual sequence content of insertions, and cover the whole size spectrum for deletions.
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Also, none of these methods can pinpoint which isoforms are involved in differential isoform usage, as individual isoforms are never identified in these methods.
We will need assessment methods, such as the synthetic association study, that can pinpoint specific defects in gene models (or other bioinformatic outputs) in the absence of experimental validation.
Nobody can pinpoint a problem.
"I can pinpoint the moment he crumbled.
I can pinpoint the exact moment when it happened.
"You can pinpoint what you want now," says one aficionado.
"It's not one thing I can pinpoint," he said.
Rolen smiled and said: "I can pinpoint why.
"I can pinpoint what happened there," he remembered.
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