In recent years, in in silico target prediction methods the promiscuity issue has generally been approached computationally in three main ways: ligand-based methods; target-protein-based methods; and integrative schemes.
The availability of the genome sequence of Y. lipolytica strain E150 (CLIB99) [ 6, 7] and the development of genetic tools, such as transformation methods [ 8], and integrative expression cassettes [ 9- 11] have increased its suitability to be metabolically engineered.
In this study, we identified 17 miRNAs using a systematic and integrative method POMA from RNA-seq based expression profile.
There are also prediction methods based on motif/domain searches, such as PRINTS [ 4], ProDom [ 5], PFAM [ 6], BLOCKS [ 7], and integrative methods that are based on some of the above-mentioned resources, such as InterPro [ 8].
The more genomic data available, the more intensive and integrative methods are needed in the future to incorporate both selection forces and demographic history influences.
That the executive summary and vision that open the National Pain Strategy are nearly devoid of explicit mention of complementary and integrative methods and practitioners is quite probably a function of who was invited to the table.
Computational methods for reconstructing GINs from expression data can be categorized into four groups: gene-pair based, single-gene targeted, gene-module based, and integrative methods [ 1].
The normalized mutual information between clustering schemes generated by individual data types and integrative methods suggested that iBFE extracted more information from the DNA methylation data than direct concatenation and SNF.
The normalized mutual information between clustering schemes generated by individual data types and integrative methods suggested that iBFE extracted more information from the mRNA expression data than direct concatenation and SNF.
LRAcluster is a computational-efficient method for fast dimension reduction and integrative clustering of large-scale cancer multi-omics data.
