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In the proposed method, an original network structure was compressed by iteratively contracting identical edges and sets of connected edges.
In our method, an original TF knockout target (inferred solely from the noisy TFKMs) is said to be biologically interpretable if a path from the knocked-out TF to this target could be identified in the TF binding network.
In our method, an original TF knockout target (identified by Reimand et al. [ 11]) is said to be biologically interpretable if a path from the knocked-out TF to this target could be identified in the TF binding network.
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Figure 15 Result of the AWB method: (a) original image, (b) Gray world, (c) Max- RGB, (d) Shades of Gray, (e) Gray Edge, and (f) Proposed method.
However, we here described (see Materials and Methods) an original protocol developed for an heterogeneous population of starting embryos, using the conditional cell lethal transgene P{hs-hid} (Grether et al., 1995).
The model combines the Carhart atomic pair method with an original similarity measure.
Remarkably the presented method offer an original tool to monitor nanoscale temperature variation in a biocompatible environment by exploiting the DNA melting process.
Our method constitutes an original way to quantitatively appreciate the liability of functional traits in a phylogenetically explicit context.
Our method regards an original TF knockout target as a false positive if no path (in the TF binding network) from the knocked-out TF to this target could be found.
The method provides an original variable's importance index for classification and regression that can be applied in other fields [ 14] for example, to assess the RS in the reprioritization component of QoL assessments.
As such, and as far as we are aware, this method provides an original and novel approach for the analysis of the cooperativity in macromolecular complexes that are part of some signalling cascade.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com