Using numerical methods, such as the finite element method (FEM), a consideration of deflections is possible but the usage is complex and extensive in engineering practice compared to recomputing guidelines or standards like VDI 2736 or ISO 6336.
Fundamental issues underlying proper use and interpretation of these methods include a) consideration of the scientific goal in experimental design, b) selection of an appropriate animal model, c) expertise of the investigator, d) adequate statistical analysis, and e) proper data interpretation.
One of the main criticisms of Zelen's method is that a consideration of sample size needs to be undertaken if the study is not to be undermined by patients opting out, or declining to be recruited [ 14, 15].
We have shown this bysimulations and through analytic methods, which include a consideration of how stochasticdynamic synapses mold the distribution of interrelease intervals (IRIs) into a form thatdiffers from the exponential distribution of incoming interspike intervals (ISIs).
There remain significant challenges within the drug discovery process to achieving this aim, most notably, the development of optimal in vitro and in vivo screening methods, an improved consideration of the importance of epitope selection and a better understanding of events at the tumour immune system interface.
This study proposes an adaptive method in consideration of an account user's preferences that are tallied, based on the frequency of user query requests during data dissemination.
Alternatively, the virtual addition of a defined rim of attenuating pixels to the outer borders of the phantom fluid visible in MR imaging may provide a method for consideration of the phantom housing in MR-based AC.
Determining the outcomes of a complex intervention requires a combination of qualitative and quantitative methods [ 23] and a consideration of the different experimental designs available [ 28].
This includes a consideration of methods for experimentally assessing the generation, maintenance, inspection and transformation of mental images; as well as subjective measures of characteristics such as image vividness and clarity.
A principle method development consideration must be how to reproducibly present the particles to the dissolution test apparatus.
