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In the study by Scheen 2006, concomitant therapy with metformin was used by 47 to 52%, sulphonylurea alone by 16%, and metformin plus sulphonylurea by 10 to 11%.
For all analyses, metformin was used as reference.
Metformin was used by 21% of the study population and sulfonylurea drugs by 44%.
Metformin was used as the positive control to compare the effects of LMWC.
Metformin was used more frequently in both Australian groups than in the remote Canadian group.
* Oral including metformin was used for all except in few with high creatinine or type 1 diabetes.
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Metformin is used by around 35 million people in the U.S alone, is able to cross the blood-brain barrier and has few contra-indications when prescribed appropriately [16], [56], [57].
The antidiabetic drug metformin is used by >100 million people with type 2 diabetes worldwide.
Can Metformin Be Used as a Generic Therapy for All Breast Cancer Sub-Types?
Metformin is used for treatment of type II (adult-onset) diabetes.
Therefore, various pharmacologic agents (e.g. thiazolidinediones and metformin) are used to enhance insulin sensitivity [ 28].
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