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Treatment with metformin was started 7 days after inoculation of the cells.
Of note, in all experiments related to the study of potential geroprotective action the treatment with metformin was started at the young age.
Rather, it is possible that colorectal cancer was present or that the adenoma to carcinoma progression was well underway before metformin was started in these patients.
Metformin was started at a dose of 500 mg/day and increased weekly by increments of 500 mg/day to a goal dose of 1,000 mg twice daily.
Metformin was started at 500 mg at breakfast and increased weekly by increments of 500 mg to a final dose of 2,000 mg/day (1,000 mg at breakfast and at the evening meal).
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These can for example be regular parts of clinical practice (e.g. metformin is started in different circumstances from thiazolidinediones), differing clinical habits in different countries (e.g. use of basal or premix insulin most commonly) or more subtle effects (choice of insulin regimen for people started on insulin as in-patients in the context of other illness).
Prevention of reproductive aging (i.e. degeneration of the estrous cycle) occurred when metformin treatment was started at any age.
Treatment with rosiglitazone/metformin was discontinued, and the patient was started on metformin and glipizide to maintain glycemic control.
At diagnosis he was started on metformin 1000 mg twice daily and his glycated hemoglobin (HbA1c) decreased from 8.6%to7.8%8.6%to7.8%
After reaching PO, rosiglitazone was discontinued, metformin was continued, and insulin glargine was started and titrated to achieve the glycemic target.
Metformin can be started on top of study medication in a dose of 500 mg three times per day, to prevent exceeding maximal metformin dose.
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