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Pancreatic metastatic tumour may also be completely asymptomatic.
One possible explanation for this clinical observation is that eribulin may suppress the incidence of new metastasis, thus providing an increased survival benefit to patients even under conditions in which the primary tumour and preexisting metastatic tumour may progress.
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Since subclinical, distant metastases occur during the early stages of melanoma development (Ossowski and Aguirre-Ghiso, 2010), detecting melanoma cells released from metastatic tumours may help to identify those melanoma patients at high risk of developing systemic metastatic disease.
Since cytoplasmic NR4A1 has been shown to mediate apoptosis in several cancer cell lines, its reduced expression in higher grade and metastatic tumours may possibly contribute to the survival of such tumour cells.
As for the formation of MPE, primary or metastatic tumours may invade the visceral pleura, affecting the normal resorptive flow of fluid from the parietal to the visceral pleura (DeCamp et al, 1997) or causing increased capillary leaking and increased fluid production (Silverberg, 1970).
In less or de-differentiated thyroid cancer, recurrent or metastatic tumour cells may lose the expression of sodium iodide symporter and decreased ability to concentrate radioiodine[ 52 ].
This suggests that cells that successfully intravasate from a highly metastatic tumour cell line may not all have or retain this phenotype.
Metastatic pancreatic tumours may also have certain imaging features that are more characteristic of their extrapancreatic sources than of primary pancreatic cancer.
Serial measurements of the diameter of an involved para-aortic lymph node in metastatic non-seminomatous testicular tumour may well increase during effective response to chemotherapy.
Therefore, it is conceivable that the ability of COX-1 to increase metastatic tumour formation in vivo may be through enhanced angiogenesis.
Background: HPV DNA has been detected in metastatic tumour and HPV plasma viraemia may indicate a poor prognosis and a high risk for metastasis.
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