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The same metastatic trend was detected in the liver, with mice in the PC3-mCD47 group having 3- and 4-fold more hepatic lesions than mice in PC3-GFP-Luc and PC-3 M-LN4 group, respectively (Fig. 4b).
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Analysis of copy number variation patterns of both metastatic sets revealed a trend similar to that seen with our single nucleotide variants.
There was a trend that metastatic brain tumors were associated with worst functioning and most severe symptoms, followed by glioma, meningioma and pituitary adenoma.
In contrast, in patients treated with trastuzumab-based therapy, increased Src activation implied poorer survival in patients at early stage (OS P=0.034) and in those with metastatic disease, as a trend (OS P=0.148).
No other significant differences or trends in metastatic patterns with respect to KRAS/BRAF genotypes were observed.
Data that directly associate utilization of novel systemic therapies with survival trends in metastatic breast cancer (MBC) are limited.
Lastly, a single nucleotide polymorphism within COMT, a gene implicated in susceptibility both to schizophrenia and to metastatic cancer, demonstrates a strong trend towards predicting the MRVA of a given cell line, even in normal subjects.
11 A second trial involving patients with metastatic disease found a nonsignificant trend toward cumulative increases in osteonecrosis of the jaw (1% in year 1 and 2% in year 2).
Intriguingly, a recent study reported that gain at the MEN1 locus was detected in a substantial proportion of human metastatic prostate cancers, and a trend toward increased menin expression in human prostate cancers and metastatic tissues was suggested by a meta-analysis of MEN1 expression data in prostate cancer [ 27].
Likewise, in AVAGAST (which evaluated capecitabine/cisplatin with or without bevacizumab in patients with previously untreated metastatic gastric cancer), there were trends towards greater benefit (OS and PFS) with bevacizumab in patients with higher plasma VEGF-A concentrations.
Not surprisingly, metastatic disease at diagnosis displayed a trend toward worse survival [Table 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com