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The unique behavior of metastatic diffusion of ovarian cancer, which initially spreads locally within the peritoneal cavity, paves the way for the local application of SEPs in the fast intraoperative detection of microscopic residual tumors during surgery.
The mechanical pressure induced by the host tissue can be circumvented by tumor invasion [18] and/or metastatic diffusion [19].
Then, a very important corollary to our work could perhaps be the study of metastatic diffusion, since the parameters of secondary neoplasies would be as well related to the ones of the primary tumor.
Hif-1 α was the most discriminatory biomarker for the presence of metastatic diffusion.
It is involved in cell adhesion and recognition in various biological processes including embryogenesis, hemostasis, tissue repair, immune responses, and metastatic diffusion of tumor cells.
In HCC patients, prognosis and survival are still unsatisfactory mainly because of tumour recurrence and metastatic diffusion (Giannelli et al, 2002b).
Similar(41)
In the context of bone marrow assessment by metastatic disease, diffusion-weighted (DW) MRI is increasingly being used because it is sensitive to bone marrow cell density, the relative proportions of fat and marrow cells, water content and bone marrow perfusion.
In the 239 histologically proven metastatic lymphadenopathies, the mean apparent diffusion coefficient (ADC) value was 0.903 × 10−3 mm/sec.
However, there are persistent cautions that some metastatic lesions may show restricted diffusion and mimic the appearances of abscesses, for example two different studies have reported this pattern for non-small cell lung carcinoma metastases, while others have also described it for lymphoma [ 35- 38].
In view of these considerations, on diffusion-weighted images metastatic lesions reproduce different signal intensity on the basis of their cellularity [ 41].
Therefore, DMS may play a role in allowing therapeutic MNPs to reach areas of poorly vascularized metastatic tumours more effectively than by diffusion alone.
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