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Therefore, exploring multimodal nanotheranostic agents for diagnosis and treatment of metastatic LNs are desired.
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Metastatic LNs were observed in less of samples with LNs (>12) than samples with <12 LNs.
Metastatic LNs were observed in 8 % of samples with LNs (>12) vs. 13%% of samples with <12 examined LNs (P = 0.1).
Metastatic LNs were observed in 8 % of samples with adequate number of examined LNs and in 13 % with less than 12 examined LNs (P = 0.1).
The expression levels of Pyk2 and Pyk2[pY881] in the matched metastatic lymph nodes of 47 NSCLC patients were also evaluated, and the expression levels between the primary NSCLC lesions and metastatic LNs were compared.
19– 21 Cancer cells from the primary lesion flow through the lymphoid vessels and produce an embolus in the LN, after which metastatic LN are formed according to a regular probability.
In this study, the incidence of AGC with metastatic LN was 75.7 % (165/218) of all AGC, with a mean number of metastatic LN of 9.9 ± 9.8.
It was recently acknowledged that the total number of metastatic LN is a more reliable prognostic indicator than positive anatomical lymphatic stations.
10– 15 Therefore, in the tumor node metastasis (TNM) classification, the total number of metastatic LN was adopted to classify the stages of gastric cancer.
23– 25 In the seventh edition of the UICC classification, the number of metastatic LN was adopted as an index of the stages of a disease.
At present, the concept of sentinel LN biopsy in early stage VC is becoming increasingly accepted while the problem of optimal treatment of patients with metastatic regional LNs is still being discussed.
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