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Lysyl oxidase homolog 2 (LOXL2), also known as lysyl oxidase-like protein 2 is recently been explored as regulator of carcinogenesis and has been shown to be involved in tumor progression and metastasis of several carcinomas.
G protein-coupled receptors (GPCRs) and their ligands have been implicated in progression and metastasis of several cancers.
These include three novel intron retentions in CD44, a gene in which isoform variations have been previously associated with the metastasis of several cancers.
The phosphorylation of AKT is reported to enhance the metastasis of several tumor cells.
In previous studies, ezrin was found to have important roles in the tumorigenesis and metastasis of several malignancies.
Overexpression of MMP-2 is related to invasion and metastasis of several tumors [ 12], while EMs also have invasive behavior.
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The complex process of metastasis consists of several steps [5].
Cancer metastasis consists of several interdependent processes including uncontrolled cell proliferation, invasion through surrounding tissues, migration to the distant sites of the human body, and adhesion, invasion and colonisation of other organs and tissues (Price et al, 1997).
The invasive metastasis properties of several of the cell lines that we used in this study were examined by others before the identification of CD44+/CD24- cells, and most of these studies correlated invasive properties with ER-α status and/or expression status of mesenchymal markers such as vimentin or MMPs [ 24, 40, 41].
When introduced orthotopically, 4T1 is capable of metastasis to several organs affected in breast cancer including lungs, liver and brain, as well as bone [ 7, 9- 11].
Moreover, CTNND1 had been implicated in the metastasis and pathogenesis of several human cancers [ 63].
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