Sentence examples for metastasis of multiple from inspiring English sources

The constitutive expression of OPN has been reported to be involved in the process of tumor carcinogenesis and metastasis of multiple human malignancies [38].

Recent observations that aberrant expression of tissue transglutaminase (TG2) promotes growth, survival, and metastasis of multiple tumor types is of great significance and could yield novel therapeutic targets for improved patient outcomes.

Cx43 is an important regulator of the metastasis of multiple tumours [ 9, 26– 31].

These data support the possibility of intramucosal seeding/spreading that is analogous to intraglandular metastasis of multiple PTCs in the thyroid gland.

Chemokine receptor CXCR4 is involved in metastasis of multiple cancer entities, including breast cancer [ 62], gastric cancer [ 63], prostate cancer [ 64], melanoma [ 65], uveal melanoma [ 66], or glioblastoma [ 67], to name just a few.

The CXCR4/SDF-1 axis involvedved in migration and metastasis of multiple types of cancers, and CXCR4 antagonists like AMD3100 are known to inhibit invasion of CXCR4-expressing cancer cells.

The process of tumor metastasis consists of multiple steps, all of which are required to achieve tumor spreading., Proteins involved in metastasis are natural candidate molecular markers that can be analyzed in archived surgical samples and correlated with tumor recurrence and mortality in retrospective studies.

The process of metastasis consists of multiple sequential steps, including the escape of tumor cells into surrounding tissues, followed by their intravasation into vessels, survival in the circulatory system, extravasation, and growth into macroscopic secondary tumors in distant organs.

In cases of metastasis to multiple organs, each of the corresponding sites was included in the analysis.

Univariate analyses showed that poor survival was significantly associated with PS 3, NLR >3.1, CRP level >0.2 mg/dL, Alb level < 3.5 g/dL, CA19-9 level >37 U/mL, adjacent organ invasion, presence of bulky lymph nodes, metastasis to multiple organs, absence of gastrectomy with or without metastasectomy, and absence of chemotherapy (Table  2).

The therapeutic delivery of locked nucleic acids to silence these aberrantly expressed miRNAs significantly inhibits the metastasis of melanoma to multiple organs.