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Exact(5)

In addition, the corresponding scatter plots illustrate an excellent delineation of metastases and healthy liver parenchyma, without relevant overlap between the imaging features in both tissues.

Here, we use high-resolution, high-accuracy mass spectrometry to perform a deep analysis of luminal-type breast cancer progression using clinical breast samples from primary tumors, matched lymph node metastases, and healthy breast epithelia.

In contrast, patients with breast cancer without bone metastases and healthy controls have shown a comparable level of biomarkers.

Levels of all bone formation and bone resorption markers were significantly (P< 0.006 0.0001) higher in patients with prostate cancer and bone metastasis than in patients with benign prostatic hyperplasia, patients with prostate cancer without bone metastases and healthy controls.

Serum bone ALP (13.7±6.2 vs 9.3±2.1 ng ml−1, P=0.03 in women with breast cancer and bone metastases and healthy controls, respectively) and serum CTX (0.55±0.56 vs 0.22±0.35 ng ml−1, P=0.0004) were significantly higher in women with breast cancer and bone metastases compared to healthy women.

Similar(55)

In all culture conditions, we observed a comparable osteoclastogenesis in patients without bone metastases and in healthy controls (data not shown).

The studied population included 46 patients affected by newly diagnosed CaP (37 had a primary tumour only, while 9 had primary tumour and concomitant bone forming metastases) and 20 healthy men.

To evaluate whether the enhancement of bone resorption in metastatic patients is due to an increase in OC formation, we examined the ability of in vitro PBMCs to spontaneously differentiate in OCs in patients with or without bone metastases and in healthy controls.

The melanoma TMA was constructed from frozen tissue samples of 34 malignant melanomas (5 primary tumors, 8 metastases from different organs and 21 lymph node metastases) and 6 control healthy cutaneous tissue samples.

We have demonstrated that HAL-induced fluorescence is a convenient tool that improves the contrast of fluorescing metastases against healthy tissue and allows the detection of cancer lesions that would not have been discovered by normal inspection.

The markers of bone turnover were higher in patients with bone metastases compared to non-bone metastatic patients and healthy controls (Table 1).

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