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Furthermore, when analyzed in whole animals, HAL1 appears to be expressed only during embryogenesis but not metamorphosis while the opposite appears to be true for HAL2.

The larval specific organs, such as the tail and gills, are totally resorbed during metamorphosis, while the adult specific ones, such as the limbs, develop de novo.

They undergo maturation during metamorphosis, while the primary cells already reveal complex dendritic arborisations in the larva (reviewed by Hartenstein et al., 2008).

In this study, synthase A was significantly up-regulated in wing disc during metamorphosis, while the expression of synthase B was almost undetectable (Table  6 and Figure  7D, 7E).

Critical periods for infectivity likely include the time before the larval immune system develops, at metamorphosis while the larval immune system is being dismantled, and during periods of exogenous stressors (e.g., movement of the animals from outside to inside tanks).

In this regard, it is interesting to note that the matrix metalloproteinase gene MMP9 is a single gene in mammals but duplicated in amphibians with one of the duplicated genes (MMP-9 TH) expressed in the regressing tail during metamorphosis, while the other (MMP-9) expressed in embryos [ 51].

Similar(53)

T3-treatment of premetamorphic tadpoles or tadpole organ cultures induces precocious metamorphosis while blocking the synthesis of endogenous T3 inhibits natural metamorphosis.

Some species go through metamorphosis while still inside the egg and hatch directly into small frogs.

Thus, the two HAL genes were differentially regulated during metamorphosis with HAL2 exclusively expressed in the intestinal Ep at the climax of metamorphosis while HAL1 expression was absent in the intestine throughout metamorphosis.

Indeed, transgenic overexpression of wild type PRMT1 leads to an increased number of intestinal stem cells during metamorphosis while antisense morpholino-mediated PRMT1 knockdown reduces the number of such stem cells [ 11].

As shown in Figure  4, HAL2 had little or no expression in the intestine before or after metamorphosis but was drastically upregulated during metamorphosis, while HAL1 had no detectable expression (not shown), consistent with the expression data from isolated intestinal tissues.

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