At such concentrations, these paramagnetic metal agents might become toxic when present in the body for prolonged periods, as in the case for Gd3+ described above.
One possibility is that succimer, a metal-chelating agent, altered essential metal homeostasis and increased metal diuresis, as has been suggested by a number of clinical and nonhuman primate studies (Aposhian et al. 1989; Fournier et al. 1988; Smith et al. 2000a).
Chemical cleaning agents are commercially available and they are included in six categories: alkalis, acids, metal chelating agents, surfactants, oxidation agents, and enzymes.
It is worth mentioning that GR combines the metal chelating agent GGH and β-sheet breaker RYYAAFFARR (RR).
The chemical structure of EGCG provides its ability to be a metal chelating agent, and to possess, depending on its concentration, either pro- or antioxidant activity.
Moreover, TM-3 could act as antioxidant (ORAC value was 1.5eq) and neuroprotectant, as well as a selective metal chelating agent.
DMSA molecule has been widely studied not only in the medicine field but also in the surface functionalization field due to its capacity to form strong complex as a metal chelating agent.
Intriguingly, the metal chelating agent, EDTA, also inhibited degradation of GAM56.
EDTA, a metal chelating agent, was investigated to decrease ROS generated in B16F10 cells with RK intracellularly.
The metal chelating agent, EDTA, also inhibited the disappearance of GAM56 but more specific metalloprotease inhibitors, bestatin and phosphoramidon, did not.
