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Manual annotation of such a large number of metabolites, with multiple identifiers each, is extremely laborious.
If we consider metabolic energy costs associated with biosynthesis and modification of secondary metabolites, it seems intuitive that natural selection would favor metabolites with multiple functions [14].
Amino acids serve as precursors for a large array of metabolites with multiple functions in plant growth and response to various stresses.
Additionally, quantitative covariance between 2D NMR crosspeaks may provide a means by which to identify connectivity in metabolites with multiple spin systems.
Amino acids are the structural units that make up proteins and also serve as precursors for many metabolites with multiple functions in plant growth and response to various stresses.
Among those are metabolic networks containing amino acids as intermediate metabolites, which can either be incorporated into proteins, accumulate to high levels in response to specific cues, such as proline accumulation in response to salt stress [ 1], or serve as precursors for a large array of metabolites with multiple functions.
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Glycerol kinase (GK) catalyzes the ATP-dependant phosphorylation of glycerol to glycerol-3-phosphate [14], a pivotal metabolite with multiple roles of providing the carbon backbone for glycerophospholipid synthesis, glycolysis or gluconeogenesis, and transporting reducing equivalents from the cytosol to the mitochondria for oxidative phosphorylation [14], [15].
The biochemical system is usually visualized as static map representing metabolites interconnected with multiple reactions (see [ 2], for example).
Analysis of lipid metabolites was performed with multiple reaction monitoring in negative mode.
Analyses focusing specifically on which transcripts and metabolites were correlated with multiple gross MetS-like phenotypes were also quite illustrative.
One group of authors suggested that passive hepatic congestion, accumulation of metabolites, and/or interactions with multiple medications used in the ICU may justify lower dose requirements [ 17].
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