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Using Fisher ratio analysis to assess metabolite differences between two samples, a number of metabolites were previously identified (2-methylmalate, propylmalonate, 2-phenyl-2-hydroxy propionate, 2-ethyl-3-hydroxypropionate, ribose and galactose) as being significantly higher in methanol-grown cells than succinate-grown cells [15].

Changes in these brain metabolites were previously described in patients with bipolar disorder [ 51].

Race/ethnicity differences in exposure to these phthalate metabolites were previously documented [ 40], and evidence regarding income-related differences is conflicting.

The extent of secondary metabolite gene clusters revealed by Rhodococcus genome sequences was initially a surprise because no rhodococcal secondary metabolites were previously known [ 45].

A reduction in trichome density and trichome-borne metabolites were previously shown to render OPR3-RNAi plants more attractive to M. sexta with respect to feeding and oviposition [ 40].

Similar(55)

This metabolite was previously reported to be produced by strains of the species C. glutamicum (formerly " Brevibacterium lactofermentum") [ 26].

Non-name identifiers were added for 28 metabolites that were previously only annotated with a name.

Figure 2 indicates a linear relationship between the flux-sum values and the degree of high flux-sum metabolites which were previously identified as giant strong components forming critical links in the metabolic network [ 22].

Details of the procedure for metabolite quantification were previously published [30].

Metabolites 6 and 7 were previously obtained through chemical hydrogenation of 1[15], however this is the first report of their biomimetic synthesis.

Specialized metabolites of these classes were previously isolated from kalmegh, however, their biosynthetic pathway genes were not identified [ 11, 12, 42].

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