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Toxicity studies on microbes and plants suggested that the degraded metabolites were less toxic than control dye.
The metabolites were less affected an returned faster back to initial levels (Fig. 5).
In tumour tissue, the concentration differences between midostaurin and its metabolites were less pronounced.
MECPP was detected in > 80% of serum samples, but other metabolites were less common (3 22%).
The intra-and inter-assay coefficient of variations for both metabolites were less than 7.3 and 9.7%, respectively.
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In most cases the resultant metabolites are less active than the parent drug; however, there are instances where the metabolite is as active as, or even more active than, the parent.
While several well-accepted standard operating procedures for the analysis of body fluids are available, the NMR based quantitative analysis of cellular metabolites is less well standardized.
The genotoxicity studies using the Allium cepa assay have further confirmed that the metabolites are less minimally toxic than the untreated MG.
Cross-reactivity with proinsulin and derived metabolites was less than 1%. Assay sensitivity was 3.0 pmol/L.
The route of elimination of the A-ring-derived metabolites is less clear.
Suppression of the formation of the phenolic metabolites was less pronounced for apple PAs than for Syrah PA fraction.
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