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All phthalate metabolites were detectable in > 95% of participants with the exception of MiNP and MOP, which were detected in 79%and2.5%5% of the men, respectively (Table 3).
Tramadol and its metabolites were detectable in urine between 1 and 24 h after the administration.
Low levels of these anecortave acetate metabolites were detectable for only approximately 2 weeks in the plasma after a 15-mg posterior juxtascleral depot administration to age-related macular degeneration patients.
A larger number of metabolites were detectable in samples with higher levels of inflammation as determined by relative and absolute neutrophil count.
In some samples, only carboxylated metabolites were detectable in concentrations above LODs.
Seven of the 10 urinary metabolites were detectable in ≥ 85% of samples.
Similar(47)
Note that, a positive marijuana toxicology screen was not grounds for exclusion because drug metabolites are detectable up to 30 days after last use and several medications commonly used in HIV (e.g., efavirenz, marinol) can produce positive toxicology screens.
However, metabolites are detectable longer in urine than in other matrices.
Following dosing to steady state, 5 major metabolites are detectable in the serum.
Of note, neither leflunomide and its active metabolite are dialyzable, and drug metabolites are detectable in urine and feces for prolonged periods after chronic administration.
aAggregate measure was considered > LOD if at least one of the component metabolites was detectable (i.e. if any of 16-week DEP, DETP, and DEDTP was > LOD then 16-week DE was considered LOD).
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