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Because dialkyl phosphates originate from more than one organophosphate pesticide, quantities of the six metabolites were converted to molar concentration (nanomoles per liter) and summed to obtain the total concentrations of dialkyl phosphate metabolites for each woman.
Metabolites were converted to trimethylsilyl derivatives and analyzed with an Agilent Technologies Inc. (CA) 5975 C inert XL gas chromatograph-mass spectrometer, fitted with an HP-5MS (5% Phenyl Methyl Silox) 30 m x 250 μm x 0.25 μm film thickness capillary column, as described previously [ 30].
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These metabolites are converted into reactive oxygen species that induce oxidative stress.
It shows how the metabolites are converted into each other without taking into account potential modulating arcs in the system.
Various xenobiotic and endobiotic metabolites are converted to reactive electrophiles capable of modifying cellular macromolecules perturbing their normal activities.
These potent metabolites are converted from tamoxifen through the cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5.
Hydroxylated metabolites are converted to more water-soluble forms by cytosolic sulfotransferases (SULTs) and UDP glucuronosyl transferases (UGTs) to respective O-sulfate and O-glucuronide conjugates.
Glucose, for example, splits into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate during glycolysis; these metabolites are converted into pyruvate or used for lipid biosynthesis, respectively.
The concentration of metabolites was converted to amount recovered from urine by accounting for the molecular weight of the individual C-labelled metabolites and the volume of the individual participants void and averaged across participants.
Importantly, serine is also a gluconeogenic metabolite, being converted to pyruvate by SDS.
The resulting metabolite is converted into pyruvate and succinic semialdehyde via the homoprotocatechuate (HPC) meta-cleavage degradation route (Fig. 5A).
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