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Models with the individual phthalate and paraben metabolites were consistent with the molar sum variables.
Furthermore, the findings for phthalate metabolites were consistent with earlier reports.
The fragmentation patterns of NU7026 and its plasma metabolites were consistent with the major site of oxidation being at C-2 of the morpholine ring.
The top four most abundant metabolites were consistent amongst the field and glasshouse environments with chicoric acid (DCTA) found to be the most abundant in the RILs, comprising >30% of the total phenolic compounds in both the field and glasshouse grown RILs.
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These newly detected metabolites are consistent with known pathophysiological mechanisms of aging and are in agreement with previous studies, suggesting biological plausibility of our findings.
Our finding of sex differences in multiple classes of metabolites is consistent with earlier studies on flies showing sex differences in lipid profiles (Parisi et al., 2011; Scheitz et al., 2013).
The pharmacokinetic parameter values for sunitinib, SU012662, total drug (sunitinib + SU012662), irinotecan, and its active metabolite were consistent with data previously reported for sunitinib (Faivre et al, 2006; Britten et al, 2008), as well as for irinotecan (Rea et al, 2005; Camptosar, 2008).
The 4-hydroxyphenylacetate is derived from 4-hydroxyphenylpyruvate by 4-hydroxyphenylpyruvate oxidase and the increased concentration of this metabolite was consistent with the higher level of 4-hydroxyphenylpyruvate.
The observed PK profile of selexipag and its metabolite is consistent with twice-daily oral dosing, which is a regimen that has resulted in good patient compliance when compared with more frequent dosing regimens [ 25] or with other routes of administration [ 26, 27].
Changes in the relative proportions of secondary phthalate metabolites over time were consistent with maturation of infant metabolic pathways during the first year of life.
The R f values of metabolite a and b were consistent with that of AZT-P and AZT-G, respectively (Fig. 6a, b).
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