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Moreover, the metabolites were able to kill drug resistant isolates of B. pseudomallei and also inhibit other pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Acinetobacter baumannii but not the non-pathogenic Burkholderia thailandensis, which is closely related to B. pseudomallei.
Accordingly, we have proved in vitro that RSV metabolites were able to induce the DDR, subsequent S-phase delay and apoptosis and improved the efficacy of anticancer drugs.
Again, these metabolites were able to discriminate EOC from BOT and uterine fibroids, as well as early-stage from late-stage EOC.
When tested directly on recombinant TRPM8 channels, neither oxaliplatin nor its two metabolites were able either to shift channel activation threshold towards warmer temperatures or to potentiate the amplitude of TRPM8 activity (Supporting Fig 3).
In the paper by Ivorra and coworkers [ 42] seven metabolites were able to discriminate a specific LBW metabolome, with a significant positive correlation between birth weight and proline, glutamine, free choline and negative correlation with citrulline and phenylalanine levels.
Because DE-71 and several of its hydroxylated metabolites were able to either activate and/or displace H-E2 from ER-α, We cotreated BG1Luc3E2 cells with 10−11 M E2 and one of the chemicals of interest to determine if the PBDEs were able to modify E2-induced ERE-luciferase activity.
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The authors' hypothesis for why brain damage is reportedly more common in people who chase the dragon is because certain heroin metabolites are able to cross the blood-brain barrier much easier via inhaling smoke, causing more damage than injecting or snorting do.
Interestingly, it has been shown that kynurenine metabolites are able to induce Th1 cell apoptosis [ 24].
Putative PBDE metabolites are able to activate an estrogen-responsive luciferase reporter gene construct (Meerts et al. 2001).
This is a property by which reactive metabolites are able to covalently bind to the DNA without easily being detected by the cells defense system.
It is currently unknown whether RES or its metabolites are able to accumulate at high enough concentrations in the tissues to be effective in vivo.
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