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Even though several strain-specific metabolic changes were conserved in HFD-fed mice (e.g. lipids, choline, PC in C57BL/6 and oxoglutarate in DBA/2), adaptations to HFD also involved altered levels of different sets of metabolites specific to C57BL/6 (lactate), 129S6 (PUFAs, PC), BALB/c (β-hydroxybutyrate), DBA/2 (alanine, pyruvate), and C3H (phenylacetate, creatine).
No associations were observed between neurodevelopment and metabolites specific to malathion and chlorpyrifos [ 8].
These pathways were manually reviewed based on current literature and subsequently replaced by reactions and metabolites specific to yeast.
In particular, benzoates, phenylpropanoids, coumarins, stilbenes, dihydrochalcones, and flavonoids commonly occurring in plants were included, together with metabolites specific to a single species or family.
We measured six nonspecific dialkylphosphate (DAP) metabolites in maternal and child urine as well as metabolites specific to malathion (MDA) and chlorpyrifos (TCPy) in maternal urine.
Although we observed associations between neurodevelopment and DAPs, we saw no such associations with metabolites specific to malathion (MDA) or chlorpyrifos (TCPy).
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A metabolite specific to certain cancers, and of therapeutic interest, exists in two forms, only one of which is oncogenic.
For example, knowing that the metabolite specific to parathion is present in a large percentage of children's urine samples will direct efforts to identify and then eliminate the sources of parathion exposure.
An additional explanation for the lack of expected correlation between ChE and dialkyl phosphate metabolites is that dialkyl phosphate metabolites are specific to organophosphate compounds, whereas ChE levels may reflect exposure to both organophosphate and n-methyl carbamate pesticides.
It would be particularly useful to identify metabolite signatures specific to muscle LCFA oxidation considering the importance of lipid metabolism in this tissue to whole-body insulin sensitivity.
Using statistical analyses, the metabolomes of different biological systems can be compared, which may help differentiate between them and identify potential metabolite markers specific to each system.
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