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The combined effect of these two metabolites may explain in part the apparent anti-Onchocerca activity of decoctions of C. articulatus and justifies the use of this plant as traditional medicine for the treatment of human onchocerciasis.
It would be interesting for future studies to go one step further and study how physiological differences among bat species (e.g. the ability to cope with particular secondary metabolites) may explain niche segregation at network level.
Although possible toxicity of dopamine and its metabolites may explain relative accentuation of nigral degeneration, the modality of neurotransmitter is not the major determinant for LB formation.
The enhanced rate of glucuronidation of estrogen by daidzein and its metabolites may explain the protective effect of soy isoflavones against hormonal cancers (Pfeiffer et al, 2005).
Slow and intermediate acetylators may be unable to detoxify carcinogenic metabolites efficiently; therefore, an impaired detoxification of HCA -and nitrosamine-derived metabolites may explain the greater risk of OSCC associated with low N-acetylation activity upon exposure to environmental carcinogens.
The requirement for the formation of one of these metabolites may explain the differences in species response to AAF, in terms of mdr gene expression, that we have observed.
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As demonstrated here, AS3MT genotypes significantly predict the fraction of metabolites and may explain part of the individual differences in the fraction of MMA detected and, in turn, explain differences in susceptibility to skin lesions.
It should be noted that the sensitivity of the method used to detect possible metabolites is limited, which may explain why metabolites were found in urine but not in plasma.
For example, up-regulation of biosynthetic pathways of the metabolite under study may explain its accumulation.
Involvement of soluble signaling mediators, such as ATP and/or its metabolites, may also explain heterogeneity of individual [Ca2+]i responses to bradykinin within a cell population; confocal microscopy studies showed that some cells displayed no plateau phase whereas others were not noticeably affected by bradykinin removal and continued to respond for a few minutes (see Figure 1C).
Other studies comparing biomonitoring data with NHANES have found that population-specific factors may explain higher metabolite levels or detection frequencies (Bradman et al. 2005, 2007; Fenske et al. 2005).
More suggestions(15)
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