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Cinnamaldehyde had no performance effects on growth, hay intake, hip height, or blood metabolites compared with MON or CON.
The GC-MS analysis of extracellular metabolites from the 60% methanol, 10 mM tricine (C) quenching solution, resulted in low concentrations for a number of metabolites compared with the other quenching solutions.
CSF contains a relatively limited repertoire of metabolites, compared with serum or urine, that are relatively stable with diet and medication, and on storage at room temperature for a short time [22], [29], [31].
The supernatant sample contains only very low concentrations of metabolites compared with the quenched cell extract sample, and luckily resonances from extracellular metabolites, for example signals at 1.17, 1.38, 2.28 and 2.61 ppm, do not overlap greatly with intracellular metabolite resonances.
Regression coefficients were also higher for DEHP metabolites compared with MBP for both outcomes.
25 Oral estrogen formulations have been related to higher levels of potentially toxic estrogen metabolites compared with transdermal estradiol.
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We have no data currently on how milk contamination with phthalate metabolites compares with prenatal exposure through placenta and amniotic fluid.
The toxicology and efficacy of both parent drug and metabolite need to be assessed in cases such as iododeoxydoxorubicin, in which the parent molecule is the dominant circulating species in mice, but patients have more than 10-fold greater exposure to the metabolite compared with the parent.
Drage et al. [124] administered 40 mg of simvastatin to 27 critically ill patients, who also demonstrated higher plasma levels of both simvastatin and its active metabolite compared with healthy volunteers.
The oxymorphone/oxycodone ratio was also in line with other studies, and confirms the minor amount of this active metabolite compared with its parent substance in this group.
Similarly, their lower urinary creatinine concentrations would increase the creatinine-adjusted urine concentration of the metabolite compared with that of an adult with an identical exposure.
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