Sentence examples for metabolites causing a from inspiring English sources

Moreover, the antagonistic response in the positive DHEA control with slices disappeared, once more demonstrating that DHEA was converted into more agonistic metabolites causing a positive response in the yeast androgen bioassay.

We have previously shown that POR A287P differentially affects the activity of electron-accepting steroidogenic CYP enzymes, namely a preferential inhibition of 17-hydroxylase over 21-hydroxylase, as demonstrated in vitro and also in vivo by increased urinary excretion of corticosterone over cortisol metabolites, causing a relative accumulation of steroids with mineralocorticoid-like activity (24).

Exposure to both PCB3 and its metabolites caused a significant increase in estradiol level in the medium of granulosa and theca cells derived from porcine ovary.

It is concerning that these metabolites caused an increase of [Ca2+] i at much lower concentrations than the other metabolites of BDE-47 investigated.

Several studies have shown that ATR and its individual metabolites cause an alteration of normal patterns of ovarian and estrous cyclicity when administered to adult female Long-Evans, Fisher 344, or Sprague-Dawley rats (Cooper et al. 1996, 2000; Eldridge et al. 1994a, 1999b; Wetzel et al. 1994).

However, this concentration of reactive metabolite causing an antiproliferative effect in these cells is high, and the researchers did not investigate effects of the parent compound.

Treatments with tepoxalin at 1 × 10-7 M and its active metabolite caused a minor reduction in collagen released from the explants, however, the effect of these treatments were not statistically significant.

Prasugrel, a prodrug of the thienopyridine family, after a rapid one-step conversion into a highly bioavailable metabolite, causes an irreversible block of the P2Y12 ADP receptor.

It contains 356 dead-end metabolites causing knowledge gaps in eight cellular compartments.

In the first step of the assay, test compound solution is pumped over the nanowells to generate reactive metabolites, causing reactions with DNA in the films.

In LBTMP condition, CH2-THF will eventually deplete as cells run out of folate dependent metabolites, causing dTMP (and hence dTTP) insufficiency.