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All secondary metabolites cannot be known andmeasured in the composition.
However, comprehensive chemical information on metabolites cannot be analyzed in a single chromatogram.
For the PET data, the presence of brain-penetrant metabolites cannot be ruled out for all compounds using these methods.
Such generic metabolites cannot be represented with an InChI and therefore cannot be covered by an InChI based metabolite annotation application.
However, the tissue source of these metabolites cannot be pinpointed from plasma patterns alone.
Furthermore, some metabolites cannot be mapped to any pathways.
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Equation (4) ensures that a metabolite cannot be revisited in the path.
A shadow price of zero means the metabolite cannot be used to increase growth.
1. Relative or absolute quantitation : the varying susceptibility of ionisation of each metabolite in MS leads to a specific sensitivity for each molecule, such that the abundance of one metabolite cannot be directly compared to another.
Intracellular metabolite pools can be set to three levels: high if the metabolite is present in the medium and can be imported inside the cell (hybrid signal), medium if an intracellular synthesis flux exists (internal signal), null if the metabolite cannot be produced.
Sometimes, a metabolite cannot be assumed to be balanced because there are reactions producing or consuming this metabolite that have not been taken into account in the network; for instance, this is often the case for the cofactors, ATP, NADP, etc.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com