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High rates of metabolism were hypothesized to be beneficial for endotherms when resources are abundant [6].
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Oxidative damage from endogenous metabolism is hypothesized to contribute to DNA damage [ 34] but the importance of this mechanism to breast carcinogenesis is not clear.
In undernourished pregnancies, the offspring's metabolism is hypothesized to be optimized for extrauterine environments that mirror the intrauterine experience; accordingly, the obesogenic environments that offspring of undernourished pregnancies experience often appear to trigger cardiometabolic disease in these individuals.
Originally, two distinct mechanisms were hypothesized.
None of these DGAT3s were hypothesized to play a significant role in seed oil synthesis; rather it was proposed that they are involved in general TAG metabolism.
The physiological effects of melanocortin-4 receptor (MC4-R) on metabolism have been hypothesized to be mediated individually or collectively by neuronal groups innervating the paraventricular nucleus of the hypothalamus (PVH).
A lysosomal pathway for parkinsonism centered around ceramide metabolism has been hypothesized [ 99].
Glucose metabolism has been hypothesized to improve survival of cancer cells under hypoxia which is often observed in tumors [ 27].
Nuclear peroxisome proliferator-activated receptors (PPAR), which play a central role in lipid and glucose metabolism, had been hypothesized as being involved in colon cancerogenesis.
Since these four factors are believed to be involved in angiogenesis and hypoxic metabolism, it was hypothesized that by reducing the levels of these factors, temozolomide may contribute to the reduction of angiogenesis in glioma.
Particularly, nuclear peroxisome proliferator-activated receptors (PPAR), mainly alpha and gamma, which play a central role in lipid and glucose metabolism, had been hypothesized as being involved in colon cancerogenesis [ 8- 12].
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