To determine the roles of myoglobin and the CK system in stabilizing cardiac energy state, a computational model of oxygen transport and cardiac metabolism is applied to simulate transient changes and steady states in the beating heart.
Following obtaining a qualitatively accurate simulation of wild-type metabolism, additional flux ratios were applied through FBrAtio in attempt to predict the following experimental observations [ 43, 50].
The pregnancy-associated changes in CYP3A activity, volume, and plasma protein binding identified in the midazolam semi-mechanistic metabolism obstetric pharmacokinetic model were applied to the corresponding model for nifedipine.
When the mathematical concepts of graph theory that had originally been developed for quantitative analysis of social networks were applied to metabolism, the resulting graphs shared a number of characteristics with other real-world networks.
In a pilot project, the 4 drug metabolism and transporter panels (189 SNPs) were applied to 39 DNA samples obtained from peripheral blood of chronic lymphocytic leukemia patients enrolled in flavopiridol clinical trials ongoing at The Ohio State University.
Interestingly, the sub-networks related to starch metabolism were extracted from both studies, even though different algorithms were applied.
The first genome-scale TRNs were applied to models of Escherichia coli [ 15] and Saccharomyces cerevisiae [ 16] metabolism.
These methodologies, first developed by Phelps et al. [ 13] for studying cerebral metabolism, have been applied to other tissues and have been suggested to be more reliable in reflecting glucose metabolism than the conventional method of using SUV for quantitation [ 15, 16].
In contrast, cardiac perfusion and fatty-acid metabolism SPECT are applied for diagnosing TC, detecting the myocardial damage instead.
