Exact(2)
From this value the researchers subtracted the basal metabolism value and the calories that had been converted to fat (estimated with special x-rays that reveal fat deposits).
Any base metabolism that is larger than the metabolism factor has the desired effect because arms races will dominate as soon as infinitely small size is prevented by any significant base metabolism value.
Similar(58)
Rodriguez and colleagues present iron metabolism values for patients with hematocrit < 38% on the second or third day in the ICU [ 19].
For this intervention group there was also an increase in resting state metabolism in temporal regions, but only for the participants in this particular intervention group that had initial metabolism values below 90% of normal in the temporal region.
The infusion rate at the point of maximum cardiac index (CI) during dobutamine administration was determined for each subject and the corresponding haemodynamic/clinical/oxygen metabolism values at that point were used for comparison to baseline (before dobutamine but after fluid resuscitation) values.
However, it is largely unclear whether substrates generated by autophagy necessarily contribute with the same metabolic value to cellular metabolism.
The six pathways deregulated at the time point of 6 days are the focal adhesion pathway (p-value: 0,027), the Wnt pathway (p-value: 0,048), glutathione metabolism (p-value: 0,021), basal transcription factors (p-value: 0,035), chronic myeloid leukemia (p-value: 0,044) and metabolism of xenobiotics by cytochrome P450 (p-value: 0,019).
Additionally, significantly reduced expression levels for genes involved in amino acid metabolism (P value = 8.13e-13), translation (P value = 8.17e-04), protein folding and stabilization (P value = 1.19e-06) as well as energy supply (P value = 5.36e-21) (Additional file 3: Dataset 2) were observed.
This cluster was predominantly enriched in genes involved in phosphate metabolism (P value = 9.68e-04), energy metabolism (P value = 7.49e-05), ATP binding (P value = 7.76e-06) and stress response (P value = 1.64e-04).
In KEGG pathways, down-regulated gene sets were enriched in cell cycle (p-value = 3·10−9), glutamate metabolism (p-value = 3·10−4), N-glycan biosynthesis (p-value = 2·10−3) and glycolysis/gluconeogenesis (p-value = 0.01) (Table 1).
Functional analysis of these 48 genes revealed significant enrichment in functionalities in both amino acid metabolism (P value = 1.99e-06) and C-compound and carbohydrate metabolism (P value = 7.10e-04) (Additional file 6: Dataset 5).
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