Sentence examples for metabolism of warfarin from inspiring English sources

Identification of genetic polymorphisms in enzymes involved in the metabolism of warfarin can partially predict the maintenance dose and thus potentially decrease the incidence of bleeding episodes secondary to warfarin overdose.

BACKGROUND: Amiodarone is an effective medication in preventing atrial fibrillation (AF), but it interferes with the metabolism of warfarin.

Although acetaminophen and warfarin are metabolized by different CYP isoforms (CYP2E1 and 2C9, respectively) [5], acetaminophen administered ≥ 2 g/day for ≥3 consecutive days extend PT-INR via an inhibition of the metabolism of warfarin, which might be result from the degradation of vitamin K cycle due to depletion of glutathione induced by acetaminophen [5].

Warfarin interacts with many commonly used drugs, and the metabolism of warfarin varies greatly between patients.

Excessive use of alcohol is also known to affect the metabolism of warfarin and can elevate the INR and thus increase the risk of bleeding.

Many commonly used antibiotics, such as metronidazole or the macrolides, will greatly increase the effect of warfarin by reducing the metabolism of warfarin in the body.

Clinical and genetic components that may affect warfarin metabolism in African Americans include age, weight, cerebrovascular disease, and the presence of certain variants of the hepatic isoenzyme cytochrome P450 (CYP) 2C9, the primary metabolizer of warfarin [ 28].

The enzymes CYP2C8, CYP2C18, CYP2C19 may also play a role in the metabolism of S-warfarin (Rettie et al. 1992; Kaminsky and Zhang 1997).

The functional CYP2C9*2 polymorphism (rs1799853, R144C) confers only a moderate reduction in the metabolism of S-warfarin (Rettie et al. 1994), and was not significant in univariate analysis.

In addition, CYP1A1, CYP2C8, CYP2C18, CYP2C19 and CYP3A5 may be involved in the metabolism of R-warfarin (Rettie et al. 1992; Zhang et al. 1995; Kaminsky and Zhang 1997; Huang et al. 2004).

Another ingredient Schisandra Chinensis Fructus might also increase the metabolism of the coadministered warfarin [ 171].