132 In summary, sleep loss impairs glucose metabolism and may decrease EE.
Drugs inducing CYP3A4 and/or P-gp metabolism, such as rifampin, may decrease ATV plasma concentrations and therefore compromise ATV therapeutic effect.
Therefore, alcohol-induced taurine metabolism by gut bacteria may decrease taurine available for bile acid conjugation in the liver and alter the systematic bile acid profile.
Decreased protein binding can result in higher free-drug concentrations, and organ dysfunction may decrease drug metabolism and clearance [ 33].
Alternatively, rapamycin may decrease cellular metabolism in anoxia, which would indicate that the effect of rapamycin was not due to its effects on respiration.
18 Elevated levels of inflammatory cytokines and alterations in iron metabolism together with inflammatory states may decrease endothelial nitric oxide production, which is known to stimulate the proliferation of erythroid progenitor cells, and be implicated in the development of anaemia and change of RDW.
Accordingly, administering a lower dose because the blood concentration was set low may decrease BIS if drug metabolism is slow.
Absolute cerebral glucose metabolism may be decreased by 10 30% as a result of AED use [13, 14].
Smoking may decrease organochlorine concentrations by enhancing their metabolism via smoking-related induction of cytochrome P450 enzymes (Deutch and Hansen 1999; Zevin and Benowitz 1999).
Unfavorable lipoprotein profiles and impaired glucose metabolism are linked to cognitive decline, and all three conditions may decrease lifespan.
