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Integrating RNA sequencing with metabolomics, PRKAG2 mutations that activate AMPK remodeled global metabolism by regulating RNA transcripts to favor glycogen storage and oxidative metabolism instead of glycolysis.
It has been shown that some other oncogenic factors can upregulate tumour glucose metabolism instead of HIF-1 [ 18, 19].
Unlike most antifolate drugs, TMQ is mainly eliminated by hepatic metabolism instead of renal excretion, with a terminal elimination half-life of 15 20 h.
Recent studies have shown that readout of this reporter-based assay for some genes may reflect changes in nucleotide metabolism instead of telomeric-silencing defects (Rossmann et al. 2011; Takahashi et al. 2011).
Thus, we cannot exclude the possibility that this candidate gene (CYP, PPN070H11) could be involved in lactone production by, for example, controlling a hormone metabolism instead of participating directly in lactone biosynthesis.
In addition, Fig. 1c shows that the rate of glycolysis is significantly higher in HPSCs compared to the MPB mononuclear cells, suggesting that human HPSCs rely primarily on glycolytic metabolism instead of mitochondrial oxidative phosphorylation.
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In addition, a large number of cell wall related genes were down-regulated, this might be related to metabolism regulation instead of stress response, and it will be further analyzed below.
Inactivation of this protein would switch cells from aerobic to anaerobic metabolism, producing lactate instead of acetyl-CoA (Kim et al. 2006).
If the tumor cells could be treated to re-direct their metabolism to lipogenesis instead of erythrogenesis, perhaps the metastatic potential of the capsular vaso-mimicry could be abolished and ultimately the entire tumor replaced with fat.
In migraineurs, a reduction in mitochondrial energy would favour a metabolic shift directing tyrosine metabolism toward decarboxylation pathway instead of the hydroxylation one, leading to reduced catecholamines production and high trace amine levels in the pain matrix, and, ultimately, to the trigemino-vascular system activation, triggering the attack [1].
Growth limiting stress at cathode due to lower oxygen levels and its effective utilization by the protons and electrons coming from anode, might have diverted the microbial metabolism towards PHA synthesis instead of oxidation.
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