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Frey et al. [25] also reported regional gender differences in MDD, with higher focal tryptophan metabolism in multiple brain regions, such as the anterior cingulate cortex, inferior frontal gyrus, parahippocampal gyrus, precuneus, superior parietal lobule, and occipital lingual gyrus, in women.
Sirt1 is also a regulator of PGC-1α [32], a transcription co-activator that plays a key role in regulating mitochondrial biogenesis, adipogenesis, muscle cell differentiation, and energy metabolism in multiple tissues.
Bad has a double function: it separately regulates apoptosis and glucose metabolism in multiple cell types including neurons.
PPARγ agonists exert pleotrophic effects on glucose and lipid metabolism in multiple tissues and have become an important therapeutic agent for treating T2DM (45, 61, 62).
These data suggest that circulating levels of GLP -1 may affect to systemic metabolism in multiple organs including cardiovascular systems as a multifunctional hormone.
Further, it interacts with a large number of receptors and kinases, including sirtuin 1 and adenosine monophosphate- activated protein kinase, both of which influence the regulation of metabolism in multiple tissues.
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The biphasic profiles most likely result from metabolism occurring in multiple tissues, including the liver and at different sites within the gastrointestinal tract.
These findings suggest that laforin and SEX4 are ancient proteins that regulate an aspect of energy metabolism conserved in multiple kingdoms, namely the dephosphorylation of glycogen and starch.
These findings suggest that there may be widespread disruptions of lipid metabolism in the multiple sclerosis brain that perturbs membrane asymmetry and myelin structure.
Besides, glutamate metabolism is important in multiple other metabolic pathways, and in particular in the replenishing of the tricarboxylic acid (TCA) cycle through its oxidative deamination in mitochondria by glutamate dehydrogenase to α-ketoglutarate (reviewed in [45]).
Various adipokines have been proposed to be involved in bone metabolism via multiple effects on the formation and resorption of bone [ 2].
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