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Based on established principles of PET metabolic imaging using tracers of substrate metabolism, development of radiolabelled amino acids has been seen as a means to address the limitations of FDG with respect to specificity for cancer and also for sensitivity of lesion detection in the brain where high background uptake can mask tumoral radiotracer accumulation.
Molecular imaging using PET in small rodents requires commonly the knowledge of the input function of the tracer (quantitative and kinetic studies of the metabolism, development of new drugs or new tracers, etc).
It is required for energy metabolism, development of the skeletal system, activation of certain enzymes, function of reproductive hormones, and antioxidant functions that protect cells [ 1, 2].
Genes associated with photosynthesis, carbohydrate and lipid metabolism, development of the cell wall and membrane organization were uniquely upregulated between vegetative stages in thiamethoxam-treated plants.
A large number of rodent studies have shown that BPA can adversely affect endpoints including the development of the male and female reproductive tracts, obesity and other aspects of metabolism, development of the brain and neurobehaviors, and development of the mammary gland and its response to chemical carcinogens (reviewed in [ 23- 27]).
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The functional categories of these DEGs showed similar enrichment patterns for each comparison, including categories of metabolism, development, cellular transport, and interaction with the environment (data not shown).
In mammals, the intestinal microbiome influences host metabolism, including development of metabolic disease.
We include in the study SNPs of genes related to glucose metabolism [ 22, 23], fatty acid metabolism, and development of an atherogenic profile in MetS patients.
As the most well-understood methylotroph, M. extorquens AM1 is a potential platform for converting methanol to biofuels, building on the elucidation of pathways involved in C1 and C2 metabolism and development of tools for metabolic engineering.
Low serum concentrations of 25-hydroxyvitamin D [25(OH D] have been linked to disturbances in glucose metabolism (1– 3), development of type 2 diabetes (4), and increased risk of the metabolic syndrome (5– 7).
The link between OA and type 2 diabetes suggests that alterations in glucose metabolism directly affect joint integrity independently of body weight and creates room for hope that adequate control of glucose metabolism hampers development of OA.
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