We have proposed a semi-mechanistic pharmacokinetic model of drug metabolism, based on standard one- or two-compartment models and incorporating both hepatic and intestinal metabolism.
A potential metabolic engineering target for altering NADPH metabolism based on metabolic flux analysis is discussed.
Together, these results suggest that Atf4 mediates a shift from a metabolism based on oxidative phosphorylation to one more heavily reliant on glycolysis, reminiscent of aerobic glycolysis or the Warburg effect observed in cancer and other proliferative cells.
Consequently, metabolomics science the quantitative measurement of metabolism in conjunction with metabolic modelling is a key discipline for the functional interpretation of whole genomes and especially for testing the numerical predictions of metabolism based on genome-scale metabolic network models.
In the same way that global classification of the spaces of protein sequences and structures provided important biological information, studies of metabolism based on global classifications such as the one proposed here may also provide valuable data.
The midazolam model developed by Andrew et al. included changes in metabolism based on a wealth of metabolic data and time-dependent physiological changes due to gestation.
We constructed a constraints-based genome-scale stoichiometric model of S. coelicolor metabolism, based on earlier similar models [ 5, 6], and integrated the model predictions with a large gene expression dataset [ 7].
We subsequently focused on human NAD metabolism, based on sequence variation and divergence of 50 human NAD metabolic enzymes to elucidate candidate enzymes with sequence patterns that are consistent with an evolutionary functional transition.
Architecture metabolism based on the linearity of time and growth.
First, we considered gene essentialities in metabolism based on the ability to carry flux towards biomass formation.
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Syst Biol 4, 140, doi 10.1186/1752-0509-4-140 (2010).
