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With NE- and SB-stress (high- or low-dose) in the normal control mice, there was a matched increase in MBFi and MVO2, i.e., OEFi ratio values were very close to 1.0 confirming the close coupling of metabolism and flow under normal conditions.
This deficiency impacts carbon metabolism and flow which may induce accumulation of noticeable levels of TAG in sta6-1 mutants [ 6].
In addition, metabolism and flow decrease in depressed humans in the sgACC/ventromedial PFC in response to chronic treatment with antidepressant drugs, vagus nerve stimulation or deep brain stimulation of the sgACC or anterior capsule (Mayberg et al. 2005; Drevets et al. 2002a; Van Laere et al. 2006; Mayberg et al. 1999; Nahas et al. 2007; Conway et al. 2006).
Metabolism and flow decrease in these regions as a common functional anatomical effect of both antidepressant drug treatment and deep brain stimulation of the sgACC or anterior capsule (Mayberg et al. 2005; Drevets et al. 2002a; Van Laere et al. 2006; Mayberg et al. 1999), despite the diverse mechanisms underlying these treatments.
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The larger pathway begins with the compound GTP in purine metabolism and flows into the one carbon pool by folate pathway through C00415 dihydrofolate (DHF).
Analysis of metabolic network are based on the sequential coupling of neuronal activity, brain metabolism, and blood flow, which more closely represent the neuronal networks than blood flow networks.
Owen placed Bainbridge in a PET scanner, a machine that records changes in metabolism and blood flow in the brain, and, on a screen in front of her, projected photographs of faces belonging to members of her family, as well as digitally distorted images, in which the faces were unrecognizable.
Our hypothesis assumes that increased blood circulation is stimulated in order to improve the metabolism and blood flow of the treated structures.
These changes in the OEFi ratio suggest an uncoupling of metabolism and blood flow, as might be expected in these animal models of endothelial dysfunction.
Such factors might be expected to operate in white matter as well as gray matter, because (a) the balance between oxidative metabolism and blood flow is similar in white and gray matter (as evidenced by similar oxygen extraction fractions in white matter [56], [57]), and (b) CBF and CBV are only 2 3 times lower in white matter than in gray matter [57] [60].
In the current study our experimental procedure of performing real-time imaging rather than post-mortem analysis of brain slices offers many significant and obvious advantages, however there are factors that may affect interpretation of our findings including potential changes in cerebral metabolism and blood flow due to the anesthetic that is required to avoid movement artifacts.
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