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Gene ontology functional analysis of the differentially expressed genes indicates that surface modification of MPLA biomaterial has an extensive influence on cells by regulating expression of genes related to cell proliferation, cell cycle, cytoskeleton organization, ossification, bone remodeling, metabolism, and eventually induces osteoblast proliferation and differentiation.
Some models have been used in synthetic biology to affect metabolism and eventually control the biological processes toward desired outputs [2].
Alcohol interferes with key enzymes in one-carbon metabolism and eventually causes impaired AdoMet levels [ 13] and inhibition of DNA methyltransferases by S-adenosylhomocysteine (AdoHcy) [ 14, 15].
Hence, a complex interaction between genotype, macro- and micro-climate and plant vigor will define berry metabolism and eventually wine quality [ 10].
In contrast, when hormone, nutrient or energy levels drop below a critical level, TORC1 is inhibited, causing the cell to switch from anabolic to catabolic metabolism and eventually enter a quiescent state (Barbet et al., 1996; Duvel et al., 2010; Loewith and Hall, 2011).
On the other hand, in patients presenting mild renal failure without evident cause and a clinical record of hypothyroidism (as the ones that motivated our interest in thyroid metabolism), it may be helpful to determine thyroid metabolism and eventually to adapt the hormone therapy.
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The resulting model turned out to provide qualitatively reasonable and even semi-quantitatively accurate predictions of critical systemic responses of the dopamine metabolism and may eventually serve as a computational platform for rational drug development and biomarker screening for PD.
In the context of osteoporosis, human intervention studies have been designed to test whether the administration of alkalinising salts may favourably affect Ca and bone metabolism and therefore eventually be developed as anti-osteoporotic therapy.
"If you change calories, your metabolism slows down and eventually you reach a plateau".
At the extremes, both insufficient (i.e. starvation) and excessive (i.e. overweight and obesity) energy intake cause unfavorable alterations in body composition, metabolism, and organ function, eventually leading to premature death.
Indeed, RAS activates the RAF/MEK pathway and also activates the PI3K pathway that can activate glucose transport and metabolism, eventually explaining the differences between glucose metabolism observed in these different models of OIS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com