This suggests that T-DNA may require a metabolically active tissue for activation and efficient functioning.
For this reason, bone is a metabolically active tissue, and bone metabolism is a complex series of event under the control of different genetic, hormonal, and biochemical factors.
TOI is a tissue optical index of metabolism that provides contrast for metabolically active tissue, developed for identifying tumors [ 45], and is given by TOI = ctHHb × water/(% lipid).
Sarcopenia is an advanced age-related loss of skeletal muscle and function, which reduces the amount of metabolically active tissue, thus, increasing the risk for metabolic diseases [ 1, 2], and negatively impacts mobility, limiting the independence living and quality of life of elderly individuals [ 3, 4].
This glucose analogue accumulates in metabolically active tissue, yielding a signal that is proportional to glycolytic activity.
Visceral adipose tissue is a metabolically active tissue that is highly involved in regulating different specific metabolic processes, including lipid metabolism, glucose homeostasis, angiogenesis, hemostasis, and blood pressure as well as the modulation of inflammation responses [ 1– 5].
Although it is well established that metabolic inflammation disrupts cellular metabolism and impairs insulin signalling in metabolically active tissues, the underlying mechanisms are as yet ill-defined [ 2].
It is well known that metabolic activity uses oxygen; therefore, blood in the vicinity of metabolically active tissues will have a different proportion of oxygenated to deoxygenated haemoglobin (Hb) than that surrounding quiescent tissue.
We next sought to analyze metabolic changes and insulin responsiveness in metabolically active tissues.
This decrease in specific intrinsic demand could be due to a decrease in the proportion of highly metabolically active tissues (the midgut) or to a decrease in mitochondrial activity in individual cells.
A better understanding of the molecular changes that occur in metabolically active tissues, including adipose tissue, may increase our understanding of feline metabolism, identifying methods for promoting weight maintenance.
