Sentence examples for metabolic vulnerabilities from inspiring English sources

Unlike other studies that have previously predicted metabolic vulnerabilities using a theoretical model of cancer metabolism, here we interpreted all datasets in a sample-specific manner (Folger et al., 2011).

Understanding the similarities and differences of metabolic vulnerabilities of T cells and cancer may lead to the development of single-target or combination-based therapies to modify metabolism of the tumor niche thereby targeting both cancer cells and immune cells.

In this review, we examine dynamic aspects of how metabolic dependencies develop in cancer, shaped both by genotype and biochemical environment, and review how these interlaced processes generate targetable metabolic vulnerabilities.

The search for new drugs capable of blocking the metabolic vulnerabilities of human tumors has now entered the clinical evaluation stage, but several projects already failed in phase I or phase II.

Thus, either inhibition of a driving TK or the development of TK resistance can alter the dependence of leukemia cells on mitochondrial carbon use, engendering new metabolic vulnerabilities.

Putting all these information together, we then analyzed each sample in our dataset in the context of the cancer study it belongs to to identify potential metabolic vulnerabilities.

Their metabolic vulnerability or their increased toxicity may represent a significant drawback.

Asparagine reliance of sarcoma cells may represent an actionable, metabolic vulnerability with potential anti-RMS therapeutic value.

Asparagine reliance of sarcoma cells may represent a metabolic vulnerability with potential anti-sarcoma therapeutic value.

Another important issue is the temporal window of metabolic vulnerability to sleep loss.

We speculate that asparagine reliance of sarcoma cells represents a metabolic vulnerability that could be exploited therapeutically to inhibit rapid tumor growth.