Sentence examples for metabolic transformations from inspiring English sources

These generic metabolites represent whole classes of structurally similar metabolites that undergo the same metabolic transformations in vivo.

As described in the previous sections, cancer cells exhibit critical metabolic transformations induced by mutations that result in cell cycle deregulation associated with enhanced cellular stress.

In the current study we investigated how the products of metabolism differ from their parent molecules by analysing a large dataset of experimentally determined metabolic transformations (Figure 1).

In some cases, for metabolic transformations catalysed by cytochromes P450, it is difficult to construct the structures of the metabolites based only on knowledge of the SOMs.

The action of various cytochrome P450 (CYP) isoforms is predictable in that there are several organic structural elements that are principal targets for metabolic transformations.

Furthermore, the strength and durability of the C-F bond compared with the С-Н bond (116 and 100 kcal/mol respectively) allows undesirable metabolic transformations to be avoided.

The metabolic transformation is a switch from an oxidative metabolism to a glycolytic metabolism that is reversibly dependent on external glucose concentrations [ 2].

Our work provides a novel approach to investigate how post-translational modifications of enzymes regulate metabolism and could have important implications for understanding the metabolic transformation of FH-deficient cancers with potential clinical applications.

Furthermore, utilizing the genome-scale metabolic models (GSMMs), Yizhak et al. [ 39] proposed a metabolic transformation algorithm (MTA) to search for targets that could restore the metabolism within the cell from the source (disease) state to the target (healthy) state.

Creatinine is metabolized from creatine, which is released by the muscles, therefore muscle mass and metabolic transformation of creatine have an impact on serum creatinine concentration [ 1].

In most instances the underlying cause is the inheritance of a mutated enzyme, the normal function of which is the metabolic transformation of one metabolite into another, or of a mutated transport protein, the normal function of which is to assist in the movement of a compound across a cell membrane.