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The current paper analyzes and gives a nonlinear synthesis of a frequently used ICU metabolic system model's redefined version.
Using a clinically validated ICU metabolic system model's redefined version, an H∞-type robust controller is proposed and compared with a non-conservative complex μ-synthesis method, where robust stability and nominal performance is met under multiplicative uncertainty.
13613_2011_39_MOESM1_ESM.DOC Additional file 1: Appendix: Metabolic System Model.
13613_2011_11_MOESM1_ESM.DOC Additional file 1: Appendix: Metabolic System Model and Insulin Sensitivity (SI).
Insulin sensitivity is identified hourly for each patient using recent BG measurements and a computerized metabolic system model.
However, these models can be readily created from existing clinical data for any reasonably similar metabolic system model [29, 30, 32].
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Accurate metabolic system models are a critical element of automatic control.
In other words, having done an experimental study of a metabolic system, a mathematical model consisting of rate equations is formulated; and the simulations are used to test hypotheses that relate to control of the reaction network.
Besides, the surrounding environment of a metabolic system can be modeled by setting bounds over the exchange fluxes.
Although we used a metabolic system as the working model, the application of our method is not confined to metabolic systems.
For this metabolic system, a detailed kinetic model (Jamshidi, 2001) is readily available for validation, by simulating the steady-state metabolic flux after gene knockouts.
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