Sentence examples for metabolic switch has from inspiring English sources

Since this metabolic switch has been recognized as an indispensable feature of neoplastic tissue, genes involved in metabolism have become promising targets for cancer therapy; accordingly, the involvement of cellular metabolism in the development and progression of cancer has gained increased attention in recent years.

Different aspects of metabolic switching have already been studied in detail and published by us based on the cultivations and respective fermentation data included in the present study [ 19- 25].

Following decades when the focus has been dominated by interest in mutations in oncogenes and tumour suppressor genes as drivers of autonomous cancer cell growth, a resurgence of interest in cancer cell metabolism has partly arisen from observations that many of these oncogenes and tumour suppressor genes actually control elements of the metabolic switch that has to occur in cancer cells.

The switch has clearly served him well.

Although the molecular mechanism for this metabolic switch to aerobic glycolysis has not been fully elucidated, it is likely that mitochondrial damage to the electron transport chain and the resulting increased production of reactive oxygen species are significant driving forces.

Prof. Manolis Kellis and his colleagues have discovered a metabolic switch linked to obesity, reports Chukwuma Muanya for The Guardian.

In this study, we have explored the metabolic switch in Streptomyces coelicolor, the model organism of the antibiotics producing genus Streptomyces.

Given that PDK1 participates in the metabolic switch of the cancer cells, targeting PDK1 has become a novel therapeutic option in some cancers (Fujiwara et al., 2013).

In this context, the present study addresses a fundamental question of how subtle mitochondrial dysfunctions have causative role in the metabolic switch in transformed cells.

In addition, CR does not enforce a metabolic switch to respiration since this organism cannot ferment and has no options other than respiration.

Our laboratory has been involved in addressing the question of metabolic switch (i.e. mitochondrial pathway to aerobic glycolysis pathway) from the mitochondrial point of view and more specifically by investigating the role of mitochondrial complex I in facilitating the metabolic switch in transformed cancer cells.