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This is required to provide sufficient metabolic substrate for viability and normal function throughout the experimental period.
Pellerin and Magistretti [18] hypothesized that Lac, and not glucose, was the main metabolic substrate for activated neurons, as part of the so-called astrocyte-neuron Lac shuttle (ANLS).
Glucose is the primary metabolic substrate for the macrophage and efficient glucose influx is essential for optimal macrophage function.
In addition, arginine is an essential metabolic substrate for immune cells and required for normal lymphocyte function [ 6].
Glutamine serves as a metabolic substrate for enterocytes and immune cells, thus supporting intestinal barrier function and immune responses [ 56].
Although glucose is the main metabolic substrate for neurons, ketones are capable of fulfilling the energy requirements of the brain.
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Mass loss from oxidation of metabolic substrates for energy production and fluid losses from sweat inevitably leads to a decrease in BM, and this loss is amplified by greater energy requirements from increasing race durations and distances [7].
Typically these functions include segregation, maintenance, and support of neurons, including clearance and release of extracellular glutamate [5], [6], scavenging of oxygen free radicals [7] and homeostatic maintenance of extracellular ionic environment and pH [8], [9] These functions provide metabolic substrates for neurons [10], and couple cerebral blood flow to neuronal activity [11].
The use of metabolic substrates for ATP production has been shown further to vary between species (Storey, 2008).
For example, prebiotics such as inulin or fructose oligosaccharides increase luminal numbers of Bifidobacterium species and concentrations of protective short-chain fatty acids, which are important metabolic substrates for colonic epithelial cells.
Canola supplements are effective dietary energy sources because they are involved in the production of volatile fatty acids which serve as lipid metabolic substrates for the synthesis of glucose, fats and carbohydrates for lactation.
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