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Results obtained confirm the general trend of reductive evolution, especially metabolic simplification based on sugar availability.
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Again, this is a simplification, based on a hypothetical Earth that orbits at uniform speed around the Sun.
The approach discussed here is a simplification based on the concept of partition analysis and uncoupling (19).
Here, we made a second simplification based on the observation that changes in CCI size approximately follow a Poisson distribution, with the exception for changes ≥ 6 (Fig. 2 ).
However, the correctness of simplifications based on these assumptions is difficult to test.
Other simplifications based on graph sparsification have been proposed by Koutis, Levin and Peng [55].
Practically, there exist only very few guidelines in the literature for deriving model simplifications based on the QEA and QSSA.
Metabolic simplification via the loss of genes for carbohydrate metabolism has been associated with adaptation of other LAB species to the nutrient-rich milk environment [ 32- 35].
In this paper, we have presented a strategy for model simplification and reduction based on the CSP method.
bulgaricus genome has undergone a rapid reductive evolution as gene loss and metabolic simplification, known to be the central trend of evolving LABs [5].
In lactic acid bacteria, adaptation to the rich dairy niche is associated with gene decay, leading to metabolic simplification and auxotrophy.
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