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Through such interaction, G. sulfurreducens triggered a significant metabolic shift for C. pasteurianum that enhanced the production of PDO at the expense of butanol and ethanol.
Since the PA pathway genes were not significantly altered in BCC1617, it would be interesting to follow up if the p-hydroxybenzoate degradation pathway may provide an alternative metabolic shift for B. cenocepacia to evolve its antibiotic resistance.
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A metabolic shift from fermentation to respiration appears to be responsible for long CLS in calorie-restricted cells as well.
For example, DeRisi et al. [ 1] investigated the gene-expression response accompanying the metabolic shift from fermentation to respiration in the yeast Saccharomyces cerevisiae.
The genes showing the largest expression values in ookinetes included many glycolysis genes such as glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase, which are not highly transcribed during gametocytogenesis, reflecting a metabolic shift needed for development within the mosquito midgut.
We found that down-regulation of ISCU1/2 decreased Fe-S-dependent mitochondrial respiration and promoted a metabolic shift toward glycolysis for energy production.
Therefore, we suggest that Warburg effect be considered more as a causative agent than as a metabolic shift required only for tumor progression.
PPARα activation increases the expression of a number of proteins associated with fatty acid oxidation, and is therefore a mechanism for a metabolic shift towards fat metabolism [ 59].
This metabolic shift is potentially relevant for cognition as lactate is the primary energetic source for the brain.
This metabolic shift in is required for the rapid cell proliferation, rather than energy production.
Loss of photosynthesis has occurred independently in several plant and algal lineages, and represents a major metabolic shift with potential consequences for the content and structure of plastid genomes.
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