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In spite of these progresses, the regulatory mechanism underlying the acids secretion and solvents formation as well as their metabolic shift are still not well understood.
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We next examined if the miR-155 mediated metabolic shift is also valid in human cancer.
Understanding how cancer cells drive such metabolic shift is crucial to identify potential targets for cancer therapeutics.
This metabolic shift was clearly induced by a small electron uptake that represented less than 0.6% of the electrons consumed by C. pasteurianum.
This metabolic shift is thought to be associated with lactic acidosis, organ dysfunction and poor clinical outcomes.
Increased glycolysis has been consistently observed in cancer cells [28], [29], but whether this metabolic shift is a consequence or cause of cancer remains controversial [30].
Therefore it is likely that such a metabolic shift was also involved in our fermentation tests.
This metabolic shift is known as aerobic glycolysis, or the Warburg effect.
Furthermore, the metabolic shift is reflected in many sustaining pathways supporting the results.
This metabolic shift is often called the Warburg effect (or Warburg hypothesis).
This metabolic shift is potentially relevant for cognition as lactate is the primary energetic source for the brain.
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